Differences between the odor percepts of 10 1,3-dialkylbenzenes and 10 2,6-dialkylpyridines are based mainly on two perceptual dimensions. The overall perceptual similarity of the identically substituted benzene/pyridine pairs seems to depend on accessibility to the pyridine nitrogen atom and steric hindrance to the aromatic ring in a non-monotonic way. However, a linear relationship between a unidimensional percept and steric hindrance exists. This conclusion is based on multidimensional scaling and odor profiling studies. This set of odorants may help to elucidate the receptor mechanisms underlying odor discrimination.
This article appears as:
Seeman, J. I., Ennis, D. M., Vecor, H. V., Clawson, L., and Palen, J. (1989). The perceptual similarity of substituted benzenes and pyridines as a function of steric hindrance. Chemical Senses, 14(3), 395-405.
The perceptual similarity of substituted benzenes and pyridines as a function of steric hindrance
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